Exploring Possible Causes Linked to the Recent Upsurge in Toxoplasmosis Cases in Sudan's North Kordofan State
DOI:
https://doi.org/10.47941/ijhmnp.1818Keywords:
Toxoplasmosis, Toxoplasma Gondii, miscarriage, SudanAbstract
Purpose: Toxoplasmosis is a prevalent parasitic ailment that has been detected in a wide range of warm-blooded organisms, encompassing both domesticated animals and human hosts. This study aimed to investigate potential risk factors associated with the increasing incidence of toxoplasmosis in North Kordofan State, Sudan.
Methodology: This descriptive investigation was undertaken in El-Obeid, North Kordofan State, Sudan, between January and March of 2024. Around 155 samples were acquired from women who had undergone miscarriages or had a prior history of miscarriage. A venous blood sample was collected from every participant in order to perform serological analyses, such as ICT and ELISA.
Results: The study group had a prevalence rate of 11.6% for Toxoplasma infection. The positive instances were evenly distributed across all age groups. The highest number of positive cases were observed among individuals with secondary education, followed by those with basic education and university education, accounting for 44.4%, 27.8%, and 16.7%, respectively. The majority of positive cases, accounting for 94.4%, have reported "cat contact." The odds ratio (95% confidence interval) for cat contact in toxoplasmosis is 7.7766 (1.0023 to 60.3384), with a p-value of 0.05
Unique Contribution to Theory, Policy and Practice: Toxoplasmosis exhibits a high prevalence throughout the North Kordofan state of Sudan, maybe contributing to the heightened incidence of miscarriage within the region. The primary mode of transmission of infection is through contact with cats.
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References
- Kota AS, Shabbir N. Congenital Toxoplasmosis. 2023 Jun 26. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan–. PMID: 31424812.
- İnci A, Sohel MH, Babür C, Uslu S, Karademir GK, Yürük M, Düzlü Ö, Kızgın AD, Yıldırım A. An Overview of One Health Concept Focusing on Toxoplasmosis. Turkiye Parazitol Derg. 2023 Dec 27;47(4):256-274. English. doi: 10.4274/tpd.galenos.2023.38039.
- Fortin O, Mulkey SB. Neurodevelopmental outcomes in congenital and perinatal infections. Curr Opin Infect Dis. 2023 Oct 1;36(5):405-413. doi: 10.1097/QCO.0000000000000946.
- Journé A, Garweg J, Ksiazek E, Peyron F, Binquet C, Wallon M. Long-term Ocular Outcomes in Congenital Toxoplasmosis Treated Perinatally. Pediatrics. 2024 Mar 8:e2023064114. doi: 10.1542/peds.2023-064114.
- Caceres A, Caceres-Alan A, Caceres-Alan T. Toxoplasma gondii infections in pediatric neurosurgery. Childs Nerv Syst. 2024 Feb;40(2):295-301. doi: 10.1007/s00381-023-05915-2.
- Rehman F, Shah M, Ali A, Ahmad I, Sarwar MT, Rapisarda AMC, Cianci A. Unpasteurised milk consumption as a potential risk factor for toxoplasmosis in females with recurrent pregnancy loss. J Obstet Gynaecol. 2020 Nov;40(8):1106-1110. doi: 10.1080/01443615.2019.1702630.
- Zeinali S, Khademvatan S, Jafari R, Vazifekhah S, Yousefi E, Behroozi-Lak T. Prevalence and risk factors of Toxoplasma gondii infection among women with miscarriage and their aborted fetuses in the northwest of Iran. PLoS One. 2023 Oct 26;18(10):e0283493. doi: 10.1371/journal.pone.0283493.
- Coutinho LB, de Oliveira MC, Araujo ECB, França FBF, Almeida MPO, Cariaco Y, Czarnewski P, Silva NM. Both C57BL/KsJ (H2d haplotype) and CB10-H2 (H2b haplotype) mice are highly susceptible to congenital toxoplasmosis. Acta Trop. 2023 Dec;248:107022. doi: 10.1016/j.actatropica.2023.107022.
- Kazemi F, Arjmand R, Dousti M, Fasihi Karami M, Barzegar G, Mohammadi A, Shams M. Toxoplasma and Risk of Spontaneous Abortion: A Meta-Analysis in A Population of Iranian Women. Int J Fertil Steril. 2023 Jan 1;17(1):7-11. doi: 10.22074/ijfs.2022.542410.1219.
- Zeinali S, Khademvatan S, Jafari R, Vazifekhah S, Yousefi E, Behroozi-Lak T. Prevalence and risk factors of Toxoplasma gondii infection among women with miscarriage and their aborted fetuses in the northwest of Iran. PLoS One. 2023 Oct 26;18(10):e0283493. doi: 10.1371/journal.pone.0283493.
- Nayeri T, Sarvi S, Moosazadeh M, Amouei A, Hosseininejad Z, Daryani A. The global seroprevalence of anti-Toxoplasma gondii antibodies in women who had spontaneous abortion: A systematic review and meta-analysis. PLoS Negl Trop Dis. 2020 Mar 13;14(3):e0008103. doi: 10.1371/journal.pntd.0008103.
- Božo Šušak, Katarina Martinović, Sanja Jakovac, Jurica Arapovi. Seroprevalence of Toxoplasma gondii among general population in Bosnia and Herzegovina: 10-Years single center experience. Clinical Epidemiology and Global Health 2023; 22: 101336. https://doi.org/10.1016/j.cegh.2023.101336.
- Wilking H, Thamm M, Stark K, Aebischer T, Seeber F. Prevalence, incidence estimations, and risk factors of Toxoplasma gondii infection in Germany: a representative, cross-sectional, serological study. Sci Rep. 2016 Mar 3;6:22551. doi: 10.1038/srep22551.
- Magboul AM, Elamin E, Tamomh AG, Mohammed HY, Suliman MA, Ibrahim RM, Hassan IM, Mohammed SM, Albashir AA, Mhmoud MM, Abakar FS, Ahmed RA. Toxoplasma gondii Infection and ABO Blood Group Association Among Pregnant Sudanese Women: A Case Study. Int J Womens Health. 2023 Aug 31;15:1375-1381. doi: 10.2147/IJWH.S419740. PMID: 37671265
- Karimi P, Shafaghi-Sisi S, Meamar AR, Nasiri G, Razmjou E. Prevalence and Molecular Characterization of Toxoplasma gondii and Toxocara cati Among Stray and Household Cats and Cat Owners in Tehran, Iran. Front Vet Sci. 2022 Jun 22;9:927185. doi: 10.3389/fvets.2022.927185.
- Amouei A, Sarvi S, Mizani A, Hashemi-Soteh MB, Salehi S, Javidnia J, Hosseini SA, Amuei F, Alizadeh A, Shabanzade S, Gholami S, Daryani A. Genetic characterization of Toxoplasma gondii in meat-producing animals in Iran. Parasit Vectors. 2022 Jul 11;15(1):255. doi: 10.1186/s13071-022-05360-1.
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Copyright (c) 2024 Hassan Yousif Adam Regal, Khalil Ali Ibraheim , Ahmed Abdelkerim Ahmed Abdallah , Salah Eldinn Eltahir Gdmaa, Hassan Mohmmed Musa , Ekhlas Alrasheid Abuelfadol , Rogeia Mahmoud Niyle , Mahadi Musa Mohammed Abdallah , Inaam Eloshary Mohammed Hayaty , Nawal Ali Ahmed , Hussain Gadelkarim Ahmed
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